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THC, as well as other cannabinoids that contain a phenol group, possesses mild antioxidant activity sufficient to protect neurons against oxidative stresssuch as that produced by glutamate -induced excitotoxicity. Incannabidiol was isolated and identified from Cannabis sativa and THC was isolated and described for its structure and synthesis in As with many aromatic terpenoidsTHC has a very low Dating a Canada guy what to expect in water, but good solubility in most organic solventsspecifically lipids and alcohols.
A total synthesis of the compound was reported in ; that procedure called for the intramolecular alkyl lithium attack on a starting carbonyl to form the fused rings, and a tosyl chloride mediated formation of the ether. Geranyl pyrophosphate and olivetolic acid react, catalysed by an enzyme to produce cannabigerolic acid,  which is cyclized by the enzyme THC acid synthase to give THCA.
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